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Antiviral Immunity in Amphibians
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
* Author to whom correspondence should be addressed.
Received: 5 September 2011; in revised form: 20 October 2011 / Accepted: 22 October 2011 / Published: 31 October 2011
Abstract: Although a variety of virus species can infect amphibians, diseases caused by ranaviruses ([RVs]; Iridoviridae) have become prominent, and are a major concern for biodiversity, agriculture and international trade. The relatively recent and rapid increase in prevalence of RV infections, the wide range of host species infected by RVs, the variability in host resistance among population of the same species and among different developmental stages, all suggest an important involvement of the amphibian immune system. Nevertheless, the roles of the immune system in the etiology of viral diseases in amphibians are still poorly investigated. We review here the current knowledge of antiviral immunity in amphibians, focusing on model species such as the frog Xenopus and the salamander (Ambystoma tigrinum), and on recent progress in generating tools to better understand how host immune defenses control RV infections, pathogenicity, and transmission.
Keywords: iridovirus; viral infection; amphibian
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MDPI and ACS Style
Chen, G.; Robert, J. Antiviral Immunity in Amphibians. Viruses 2011, 3, 2065-2086.
Chen G, Robert J. Antiviral Immunity in Amphibians. Viruses. 2011; 3(11):2065-2086.
Chen, Guangchun; Robert, Jacques. 2011. "Antiviral Immunity in Amphibians." Viruses 3, no. 11: 2065-2086.