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Antiviral Strategies for Pandemic and Seasonal Influenza
NexBio, Inc./10665 Sorrento Valley Rd, San Diego, CA 92121, USA
* Author to whom correspondence should be addressed.
Received: 11 June 2010; in revised form: 6 August 2010 / Accepted: 11 August 2010 / Published: 20 August 2010
Abstract: While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.
Keywords: influenza virus; neuraminidase inhibitors; sialic acid; RNA polymerase
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Hedlund, M.; Larson, J.L.; Fang, F. Antiviral Strategies for Pandemic and Seasonal Influenza. Viruses 2010, 2, 1766-1781.
Hedlund M, Larson JL, Fang F. Antiviral Strategies for Pandemic and Seasonal Influenza. Viruses. 2010; 2(8):1766-1781.
Hedlund, Maria; Larson, Jeffrey L.; Fang, Fang. 2010. "Antiviral Strategies for Pandemic and Seasonal Influenza." Viruses 2, no. 8: 1766-1781.