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Viruses 2010, 2(2), 468-502; doi:10.3390/v2020468

PEGylated Adenoviruses: From Mice to Monkeys

1
Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
2
Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA
*
Author to whom correspondence should be addressed.
Received: 20 November 2009 / Revised: 20 January 2010 / Accepted: 25 January 2010 / Published: 1 February 2010
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)

Abstract

Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.
Keywords: adenovirus; gene therapy; vaccine; toxicity; PEGylation; targeting; pharmacokinetics; immune response; tolerance; non-viral vectors adenovirus; gene therapy; vaccine; toxicity; PEGylation; targeting; pharmacokinetics; immune response; tolerance; non-viral vectors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wonganan, P.; Croyle, M.A. PEGylated Adenoviruses: From Mice to Monkeys. Viruses 2010, 2, 468-502.

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