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PEGylated Adenoviruses: From Mice to Monkeys
Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA
* Author to whom correspondence should be addressed.
Received: 20 November 2009; in revised form: 20 January 2010 / Accepted: 25 January 2010 / Published: 1 February 2010
Abstract: Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.
Keywords: adenovirus; gene therapy; vaccine; toxicity; PEGylation; targeting; pharmacokinetics; immune response; tolerance; non-viral vectors
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MDPI and ACS Style
Wonganan, P.; Croyle, M.A. PEGylated Adenoviruses: From Mice to Monkeys. Viruses 2010, 2, 468-502.
Wonganan P, Croyle MA. PEGylated Adenoviruses: From Mice to Monkeys. Viruses. 2010; 2(2):468-502.
Wonganan, Piyanuch; Croyle, Maria A. 2010. "PEGylated Adenoviruses: From Mice to Monkeys." Viruses 2, no. 2: 468-502.