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Viruses 2010, 2(12), 2649-2662; doi:10.3390/v2122649
Commentary

The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection

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Received: 25 October 2010 / Revised: 22 November 2010 / Accepted: 22 November 2010 / Published: 8 December 2010
(This article belongs to the Section Editorial)
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Abstract

Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.
Keywords: dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guzman, M.G.; Vazquez, S. The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection. Viruses 2010, 2, 2649-2662.

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