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Viruses 2010, 2(12), 2649-2662; doi:10.3390/v2122649

The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection

Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute of Havana, Cuba
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Received: 25 October 2010 / Revised: 22 November 2010 / Accepted: 22 November 2010 / Published: 8 December 2010
(This article belongs to the Section Editorial)
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Abstract

Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.
Keywords: dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Guzman, M.G.; Vazquez, S. The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection. Viruses 2010, 2, 2649-2662.

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