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Viruses 2010, 2(12), 2618-2648; doi:10.3390/v2122618

Jaagsiekte Sheep Retrovirus Biology and Oncogenesis

Department of Molecular Biology and Biochemistry, Cancer Research Institute, University of California, Irvine, CA 92697, USA
Author to whom correspondence should be addressed.
Received: 25 October 2010 / Revised: 22 November 2010 / Accepted: 23 November 2010 / Published: 3 December 2010
(This article belongs to the Special Issue Cell Transformation by RNA Viruses)
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Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has a serious impact on affected flocks. In addition, studies on OPA are an excellent model for human lung carcinogenesis. A unique feature of JSRV is that its envelope (Env) protein functions as an oncogene. The JSRV Env-induced transformation or oncogenesis has been studied in a variety of cell systems and in animal models. Moreover, JSRV studies have provided insights into retroviral genomic RNA export/expression mechanisms. JSRV encodes a trans-acting factor (Rej) within the env gene necessary for the synthesis of Gag protein from unspliced viral RNA. This review summarizes research pertaining to JSRV‑induced pathogenesis, Env transformation, and other aspects of JSRV biology.
Keywords: Jaagsiekte sheep retrovirus; JSRV; transformation; Env; Rej; ovine pulmonary adenocarcinoma; cancer Jaagsiekte sheep retrovirus; JSRV; transformation; Env; Rej; ovine pulmonary adenocarcinoma; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hofacre, A.; Fan, H. Jaagsiekte Sheep Retrovirus Biology and Oncogenesis. Viruses 2010, 2, 2618-2648.

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