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HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158-2280, USA
* Author to whom correspondence should be addressed.
Received: 2 September 2010; in revised form: 1 October 2010 / Accepted: 1 October 2010 / Published: 6 October 2010
(This article belongs to the Section Editorial
Abstract: HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
Keywords: HIV-1; Tat; transcription; P-TEFb; retroviruses
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Cite This Article
MDPI and ACS Style
D’Orso, I.; Frankel, A.D. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses 2010, 2, 2226-2234.
D’Orso I, Frankel AD. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses. 2010; 2(10):2226-2234.
D’Orso, Iván; Frankel, Alan D. 2010. "HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear." Viruses 2, no. 10: 2226-2234.