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Viruses 2010, 2(10), 2226-2234; doi:10.3390/v2102226

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158-2280, USA
* Author to whom correspondence should be addressed.
Received: 2 September 2010 / Revised: 1 October 2010 / Accepted: 1 October 2010 / Published: 6 October 2010
(This article belongs to the Section Editorial)
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HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
Keywords: HIV-1; Tat; transcription; P-TEFb; retroviruses HIV-1; Tat; transcription; P-TEFb; retroviruses
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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D’Orso, I.; Frankel, A.D. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses 2010, 2, 2226-2234.

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