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Viruses 2018, 10(9), 451; https://doi.org/10.3390/v10090451

Characterization of Unknown Orthobunya-Like Viruses from India

1
Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
2
National Institute of Virology, Pune 411021, India
3
School of Biology, Georgia Institute of Technology, Atlanta, GA 30322, USA
Co-first authors.
Co-last authors.
*
Author to whom correspondence should be addressed.
Received: 3 August 2018 / Revised: 20 August 2018 / Accepted: 21 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Emerging Viruses)
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Abstract

Next-generation sequencing (NGS) of agents causing idiopathic human diseases has been crucial in the identification of novel viruses. This study describes the isolation and characterization of two novel orthobunyaviruses obtained from a jungle myna and a paddy bird from Karnataka State, India. Using an NGS approach, these isolates were classified as Cat Que and Balagodu viruses belonging to the Manzanilla clade of the Simbu serogroup. Closely related viruses in the Manzanilla clade have been isolated from mosquitos, humans, birds, and pigs across a wide geographic region. Since Orthobunyaviruses exhibit high reassortment frequency and can cause acute, self-limiting febrile illness, these data suggest that human and livestock infections of the Oya/Cat Que/Manzanilla virus may be more widespread and/or under-reported than anticipated. It therefore becomes imperative to identify novel and unknown viruses in order to understand their role in human and animal pathogenesis. The current study is a step forward in this regard and would act as a prototype method for isolation, identification and detection of several other emerging viruses. View Full-Text
Keywords: Orthobunyavirus; Cat Que virus; Manzanilla virus; pathogen discovery Orthobunyavirus; Cat Que virus; Manzanilla virus; pathogen discovery
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Whitmer, S.L.M.; Yadav, P.D.; Sarkale, P.; Chaubal, G.Y.; Francis, A.; Klena, J.; Nichol, S.T.; Ströher, U.; Mourya, D.T. Characterization of Unknown Orthobunya-Like Viruses from India. Viruses 2018, 10, 451.

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