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Viruses 2018, 10(8), 444; https://doi.org/10.3390/v10080444

Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation

1
BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
2
Department of Immunobiology, University of Arizona, Tucson, AZ 85721, USA
*
Author to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 16 August 2018 / Accepted: 17 August 2018 / Published: 20 August 2018
(This article belongs to the Special Issue Recent Advances in Cytomegalovirus Research)
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Abstract

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes are maintained in a quieted state. Virus replication can be reactivated from latency in response to changes in cellular signaling caused by stress or differentiation. The past decade has brought great insights into the molecular basis of HCMV latency. Here, we review the complex persistence of HCMV with consideration of latent reservoirs, viral determinants and their host interactions, and host signaling and the control of cellular and viral gene expression that contributes to the establishment of and reactivation from latency. View Full-Text
Keywords: human cytomegalovirus; latency; reactivation; signaling; transcription factors; epigenetic regulation human cytomegalovirus; latency; reactivation; signaling; transcription factors; epigenetic regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Collins-McMillen, D.; Buehler, J.; Peppenelli, M.; Goodrum, F. Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation. Viruses 2018, 10, 444.

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