Next Article in Journal
Study of the Interactions Between Bacteriophage phiIPLA-RODI and Four Chemical Disinfectants for the Elimination of Staphylococcus aureus Contamination
Previous Article in Journal
Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
Article Menu

Export Article

Open AccessArticle
Viruses 2018, 10(3), 102; doi:10.3390/v10030102

Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam

Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK
Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), 69365 Lyon CEDEX 07, France
The London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK
On behalf of the VIZIONS consortium.
Author to whom correspondence should be addressed.
Received: 20 January 2018 / Revised: 19 February 2018 / Accepted: 23 February 2018 / Published: 28 February 2018
(This article belongs to the Section Animal Viruses)
View Full-Text   |   Download PDF [4755 KB, uploaded 28 February 2018]   |  


Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined. View Full-Text
Keywords: rodents; bats; pegiviruses; hepatitis viruses; homologues; Vietnam rodents; bats; pegiviruses; hepatitis viruses; homologues; Vietnam

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Van Nguyen, D.; Van Nguyen, C.; Bonsall, D.; Ngo, T.T.; Carrique-Mas, J.; Pham, A.H.; Bryant, J.E.; Thwaites, G.; Baker, S.; Woolhouse, M.; Simmonds, P. Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam. Viruses 2018, 10, 102.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top