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Viruses 2018, 10(1), 47; https://doi.org/10.3390/v10010047

Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know

1
Divisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
2
Divisions of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
3
Divisions of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
*
Author to whom correspondence should be addressed.
Received: 10 December 2017 / Revised: 15 January 2018 / Accepted: 16 January 2018 / Published: 20 January 2018
(This article belongs to the Special Issue Expert Views on HPV Infection)
View Full-Text   |   Download PDF [344 KB, uploaded 31 January 2018]   |  

Abstract

Human papillomavirus (HPV) infections cause a significant proportion of cancers worldwide, predominantly squamous cell carcinomas (SCC) of the mucosas and skin. High-risk HPV types are associated with SCCs of the anogenital and oropharyngeal tract. HPV oncogene activities and the biology of SCCs have been intensely studied in laboratory models and humans. What remains largely unknown are host tissue and immune-related factors that determine an individual’s susceptibility to infection and/or carcinogenesis. Such susceptibility factors could serve to identify those at greatest risk and spark individually tailored HPV and SCC prevention efforts. Fanconi anemia (FA) is an inherited DNA repair disorder that is in part characterized by extreme susceptibility to SCCs. An increased prevalence of HPV has been reported in affected individuals, and molecular and functional connections between FA, SCC, and HPV were established in laboratory models. However, the presence of HPV in some human FA tumors is controversial, and the extent of the etiological connections remains to be established. Herein, we discuss cellular, immunological, and phenotypic features of FA, placed into the context of HPV pathogenesis. The goal is to highlight this orphan disease as a unique model system to uncover host genetic and molecular HPV features, as well as SCC susceptibility factors. View Full-Text
Keywords: human papillomavirus; Fanconi anemia; orphan disease; squamous cell carcinoma; inherited cancer susceptibility human papillomavirus; Fanconi anemia; orphan disease; squamous cell carcinoma; inherited cancer susceptibility
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Khoury, R.; Sauter, S.; Butsch Kovacic, M.; Nelson, A.S.; Myers, K.C.; Mehta, P.A.; Davies, S.M.; Wells, S.I. Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know. Viruses 2018, 10, 47.

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