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Viruses 2018, 10(1), 36; https://doi.org/10.3390/v10010036

Interferons: Reprogramming the Metabolic Network against Viral Infection

1,2
and
1,2,3,*
1
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada
2
Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, Canada
3
Department of Medicine, McGill University, Montreal, QC H3A 2B4, Canada
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 9 January 2018 / Accepted: 12 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Homage to Mark Wainberg)
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Abstract

Viruses exploit the host and induce drastic metabolic changes to ensure an optimal environment for replication and the production of viral progenies. In response, the host has developed diverse countermeasures to sense and limit these alterations to combat viral infection. One such host mechanism is through interferon signaling. Interferons are cytokines that enhances the transcription of hundreds of interferon-stimulated genes (ISGs) whose products are key players in the innate immune response to viral infection. In addition to their direct targeting of viral components, interferons and ISGs exert profound effects on cellular metabolism. Recent studies have started to illuminate on the specific role of interferon in rewiring cellular metabolism to activate immune cells and limit viral infection. This review reflects on our current understanding of the complex networking that occurs between the virus and host at the interface of cellular metabolism, with a focus on the ISGs in particular, cholesterol-25-hydroxylase (CH25H), spermidine/spermine acetyltransferase 1 (SAT1), indoleamine-2,3-dioxygenase (IDO1) and sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1), which were recently discovered to modulate specific metabolic events and consequently deter viral infection. View Full-Text
Keywords: viruses; metabolism; interferons; ISGs; 25HC; IDO1; SAT1; SAMHD1 viruses; metabolism; interferons; ISGs; 25HC; IDO1; SAT1; SAMHD1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Raniga, K.; Liang, C. Interferons: Reprogramming the Metabolic Network against Viral Infection. Viruses 2018, 10, 36.

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