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Viruses 2018, 10(1), 24; doi:10.3390/v10010024

Visualizing the Nucleotide Addition Cycle of Viral RNA-Dependent RNA Polymerase

1,2
and
1,*
1
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Received: 21 October 2017 / Revised: 2 January 2018 / Accepted: 3 January 2018 / Published: 4 January 2018
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
View Full-Text   |   Download PDF [1090 KB, uploaded 4 January 2018]   |  

Abstract

Viral RNA-dependent RNA polymerases (RdRPs) are a class of nucleic acid polymerases bearing unique features from global architecture to catalytic mechanisms. In recent years, numerous viral RdRP crystal structures have improved the understanding of these molecular machines, in particular, for how they carry out each nucleotide addition cycle (NAC) as directed by the RNA template. This review focuses on a visual introduction of viral RdRP NAC mechanisms through a combination of static pictures of structural models, a user-friendly software-based assembly of the structural models, and two videos illustrating key conformational changes in the NAC. View Full-Text
Keywords: RNA viruses; RNA-dependent RNA polymerase; nucleotide addition cycle; active site closure; translocation RNA viruses; RNA-dependent RNA polymerase; nucleotide addition cycle; active site closure; translocation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wu, J.; Gong, P. Visualizing the Nucleotide Addition Cycle of Viral RNA-Dependent RNA Polymerase. Viruses 2018, 10, 24.

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