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Viruses 2009, 1(2), 91-103; doi:10.3390/v1020091
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HBV-Specific Adaptive Immunity

1,2,3,* , 1
 and
1
1 Laboratory of Hepatic Viral Diseases, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*Star), 30 Medical Drive, 117609, Singapore 2 Singapore Immunology Network, Agency of Science Technology and Research (A*Star), Singapore 3 Program Emerging Viral Diseases Unit, Duke-NUS Graduate Medical School, Singapore
* Author to whom correspondence should be addressed.
Received: 9 June 2009 / Revised: 8 July 2009 / Accepted: 16 July 2009 / Published: 27 July 2009
(This article belongs to the Special Issue Hepatitis Viruses)
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Abstract

The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in patients with resolved or chronic HBV infection and analyze how the liver environment can directly modulate HBV-immunity.
Keywords: HBV; T cells; B cells HBV; T cells; B cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bertoletti, A.; Tan, A.T.; Gehring, A.J. HBV-Specific Adaptive Immunity. Viruses 2009, 1, 91-103.

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