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HBV-Specific Adaptive Immunity
Laboratory of Hepatic Viral Diseases, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*Star), 30 Medical Drive, 117609, Singapore
Singapore Immunology Network, Agency of Science Technology and Research (A*Star), Singapore
Program Emerging Viral Diseases Unit, Duke-NUS Graduate Medical School, Singapore
* Author to whom correspondence should be addressed.
Received: 9 June 2009 / Revised: 8 July 2009 / Accepted: 16 July 2009 / Published: 27 July 2009
Abstract The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in patients with resolved or chronic HBV infection and analyze how the liver environment can directly modulate HBV-immunity.
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Bertoletti, A.; Tan, A.T.; Gehring, A.J. HBV-Specific Adaptive Immunity. Viruses 2009, 1, 91-103.
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Bertoletti A, Tan AT, Gehring AJ. HBV-Specific Adaptive Immunity. Viruses. 2009; 1(2):91-103.
Bertoletti, Antonio; Tan, Anthony T.; Gehring, Adam J. 2009. "HBV-Specific Adaptive Immunity." Viruses 1, no. 2: 91-103.
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