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Viruses 2009, 1(2), 104-125; doi:10.3390/v1020104
Review

Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection

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Received: 16 June 2009; in revised form: 23 July 2009 / Accepted: 28 July 2009 / Published: 5 August 2009
(This article belongs to the Special Issue Hepatitis Viruses)
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Abstract: The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
Keywords: Hepatitis C; genes; natural history; HLA; T cells; NK cells Hepatitis C; genes; natural history; HLA; T cells; NK cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bengsch, B.; Thimme, R.; Blum, H.E. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses 2009, 1, 104-125.

AMA Style

Bengsch B, Thimme R, Blum HE. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses. 2009; 1(2):104-125.

Chicago/Turabian Style

Bengsch, Bertram; Thimme, Robert; Blum, Hubert E. 2009. "Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection." Viruses 1, no. 2: 104-125.



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