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Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
Department of Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany
* Author to whom correspondence should be addressed.
Received: 16 June 2009; in revised form: 23 July 2009 / Accepted: 28 July 2009 / Published: 5 August 2009
Abstract: The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
Keywords: Hepatitis C; genes; natural history; HLA; T cells; NK cells
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Bengsch, B.; Thimme, R.; Blum, H.E. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses 2009, 1, 104-125.
Bengsch B, Thimme R, Blum HE. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses. 2009; 1(2):104-125.
Bengsch, Bertram; Thimme, Robert; Blum, Hubert E. 2009. "Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection." Viruses 1, no. 2: 104-125.