Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
AbstractThe natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Bengsch, B.; Thimme, R.; Blum, H.E. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses 2009, 1, 104-125.
Bengsch B, Thimme R, Blum HE. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection. Viruses. 2009; 1(2):104-125.Chicago/Turabian Style
Bengsch, Bertram; Thimme, Robert; Blum, Hubert E. 2009. "Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection." Viruses 1, no. 2: 104-125.