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Viruses 2009, 1(2), 144-165; doi:10.3390/v1020144
Review

Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV): Developments and Future Perspectives

Received: 3 June 2009 / Revised: 25 July 2009 / Accepted: 11 August 2009 / Published: 12 August 2009
(This article belongs to the Special Issue Hepatitis Viruses)
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Abstract

Studies in patients and chimpanzees that spontaneously clear Hepatitis C Virus (HCV) have demonstrated that natural immunity to the virus is induced during primary infections and that this immunity can be cross protective. These discoveries led to optimism regarding prophylactic HCV vaccines and a number of studies in the chimpanzee model have been performed, all of which resulted in modified infections after challenge but did not always prevent persistence of the virus. Therapeutic vaccine strategies have also been pursued in an effort to reduce the costs and side effects associated with anti-viral drug treatment. This review summarizes the studies performed thus far in both patients and chimpanzees for prophylactic and therapeutic vaccination, assesses the progress made and future perspectives.
Keywords: vaccine; immune responses; immunotherapy; T cells; neutralizing antibody vaccine; immune responses; immunotherapy; T cells; neutralizing antibody
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Major, M.E. Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV): Developments and Future Perspectives. Viruses 2009, 1, 144-165.

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