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Algorithms 2009, 2(1), 429-436; doi:10.3390/a2010429
Article

Protein-Protein Interaction Analysis by Docking

* ,
 and
*
Institute of Functional Genomics, University of Regensburg, Josef-Engert-Strasse 9, D-93053 Regensburg, Germany
* Authors to whom correspondence should be addressed.
Received: 1 December 2008 / Revised: 19 January 2009 / Accepted: 27 February 2009 / Published: 10 March 2009
(This article belongs to the Special Issue Algorithms and Molecular Sciences)
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Abstract

Based on a protein-protein docking approach we have developed a procedure to verify or falsify protein-protein interactions that were proposed by other methods such as yeast-2-hybrid assays. Our method currently utilizes intermolecular energies but can be expanded to incorporate additional terms such as amino acid based pair-potentials. We show some early results that demonstrate the general applicability of our approach.
Keywords: protein-protein docking; verification of protein interactions; 3D protein structures protein-protein docking; verification of protein interactions; 3D protein structures
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Fink, F.; Ederer, S.; Gronwald, W. Protein-Protein Interaction Analysis by Docking. Algorithms 2009, 2, 429-436.

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