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Materials 2016, 9(9), 728; doi:10.3390/ma9090728

Study of Different Sol-Gel Coatings to Enhance the Lifetime of PDMS Devices: Evaluation of Their Biocompatibility

Photonics4 Life Research Group, Departamento de Física Aplicada, Facultad de Física, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) SERGAS, Santiago de Compostela 15706, Spain
Author to whom correspondence should be addressed.
Academic Editor: Fu Hsiang Ko
Received: 20 July 2016 / Revised: 12 August 2016 / Accepted: 23 August 2016 / Published: 25 August 2016
(This article belongs to the Special Issue Advances in Bendable and Soft Material Film)
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A study of PDMS (polydimethylsiloxane) sol-gel–coated channels fabricated using soft lithography and a laser direct writing technique is presented. PDMS is a biocompatible material that presents a high versatility to reproduce several structures. It is widely employed in the fabrication of preclinical devices due to its advantages but it presents a rapid chemical deterioration to organic solvents. The use of sol-gel layers to cover the PDMS overcomes this problem since it provides the robustness of glass for the structures made with PDMS, decreasing its deterioration and changing the biocompatibility of the surface. In this work, PDMS channels are coated with three different kinds of sol-gel compositions (60MTES/40TEOS, 70MTES/30TISP and 80MTES/20TISP). The endothelial cell adhesion to the different coated devices is evaluated in order to determine the most suitable sol-gel preparation conditions to enhance cellular adhesion. View Full-Text
Keywords: sol-gel; laser writing technique; soft lithography; PDMS devices; cell adhesion sol-gel; laser writing technique; soft lithography; PDMS devices; cell adhesion

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Aymerich, M.; Gómez-Varela, A.I.; Álvarez, E.; Flores-Arias, M.T. Study of Different Sol-Gel Coatings to Enhance the Lifetime of PDMS Devices: Evaluation of Their Biocompatibility. Materials 2016, 9, 728.

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