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Materials 2016, 9(5), 321; doi:10.3390/ma9050321

Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines

1
Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA
2
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
3
Center of Advanced Host Defenses Immunobiotics and Translational Medicine, Iowa State University, Ames, IA 50011, USA
4
Ames Laboratory, Department of Energy, Ames, IA 50011, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jun-ichi Anzai
Received: 24 February 2016 / Revised: 22 April 2016 / Accepted: 22 April 2016 / Published: 28 April 2016
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [1671 KB, uploaded 28 April 2016]   |  

Abstract

Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs. View Full-Text
Keywords: transient platform; controlled release; polymer platform; long-term release transient platform; controlled release; polymer platform; long-term release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Acar, H.; Banerjee, S.; Shi, H.; Jamshidi, R.; Hashemi, N.; Cho, M.W.; Montazami, R. Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines. Materials 2016, 9, 321.

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