Next Article in Journal
Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides
Next Article in Special Issue
Effects of Apatite Cement Containing Atelocollagen on Attachment to and Proliferation and Differentiation of MC3T3-E1 Osteoblastic Cells
Previous Article in Journal
High Pressure Synthesis of p-Type CeyFe4−xCoxSb12 Skutterudites
Previous Article in Special Issue
Topological Design of Cellular Phononic Band Gap Crystals
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Materials 2016, 9(4), 256; doi:10.3390/ma9040256

ZnO Nanostructure Templates as a Cost-Efficient Mass-Producible Route for the Development of Cellular Networks

1
Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, Aghia Paraskevi, Athens 153 10, Greece
2
Nanobiosensorics Momentum Group, Institute of Technical Physics and Materials Science, Centre for Energy Research, Budapest 1121, Hungary
3
Doctoral School of Molecular- and Nanotechnologies, University of Pannonia, Veszprém 8200, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Xiaodong Huang
Received: 26 February 2016 / Revised: 18 March 2016 / Accepted: 18 March 2016 / Published: 31 March 2016
(This article belongs to the Special Issue Cellular Materials: Design and Optimisation)
View Full-Text   |   Download PDF [15479 KB, uploaded 31 March 2016]   |  

Abstract

The development of artificial surfaces which can regulate or trigger specific functions of living cells, and which are capable of inducing in vivo-like cell behaviors under in vitro conditions has been a long-sought goal over the past twenty years. In this work, an alternative, facile and cost-efficient method for mass-producible cellular templates is presented. The proposed methodology consists of a cost-efficient, two-step, all-wet technique capable of producing ZnO-based nanostructures on predefined patterns on a variety of substrates. ZnO—apart from the fact that it is a biocompatible material—was chosen because of its multifunctional nature which has rendered it a versatile material employed in a wide range of applications. Si, Si3N4, emulated microelectrode arrays and conventional glass cover slips were patterned at the micrometer scale and the patterns were filled with ZnO nanostructures. Using HeLa cells, we demonstrated that the fabricated nanotopographical features could promote guided cellular adhesion on the pre-defined micron-scale patterns only through nanomechanical cues without the need for further surface activation or modification. The basic steps of the micro/nanofabrication are presented and the results from the cell adhesion experiments are discussed, showing the potential of the suggested methodology for creating low-cost templates for engineered cellular networks. View Full-Text
Keywords: ZnO nanostructures; HeLa cells; selective adhesion; engineered cellular networks; nanotopography ZnO nanostructures; HeLa cells; selective adhesion; engineered cellular networks; nanotopography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Makarona, E.; Peter, B.; Szekacs, I.; Tsamis, C.; Horvath, R. ZnO Nanostructure Templates as a Cost-Efficient Mass-Producible Route for the Development of Cellular Networks. Materials 2016, 9, 256.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top