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Materials 2016, 9(11), 954; doi:10.3390/ma9110954

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

1
Department of Dentistry, School of Medicine, Korea University, Seoul 02841, Korea
2
Department of Prosthodontics, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea
3
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
4
School of Dentistry, Pusan National University, Yangsan 50612, Korea
5
Tissue Biotech Institute, Cowellmedi Co., Ltd., Busan 46986, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Georgios E. Romanos
Received: 28 September 2016 / Revised: 7 November 2016 / Accepted: 17 November 2016 / Published: 23 November 2016
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [9599 KB, uploaded 23 November 2016]   |  

Abstract

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2. View Full-Text
Keywords: alloplast; bone substitutes; biphasic calcium phosphate; calcium pyrophosphate; rhBMP-2 alloplast; bone substitutes; biphasic calcium phosphate; calcium pyrophosphate; rhBMP-2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, J.-C.; Bae, E.-B.; Kim, S.-E.; Kim, S.-Y.; Choi, K.-H.; Choi, J.-W.; Bae, J.-H.; Ryu, J.-J.; Huh, J.-B. Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration. Materials 2016, 9, 954.

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