Next Article in Journal
Effect of Glucose Concentration on Electrochemical Corrosion Behavior of Pure Titanium TA2 in Hanks’ Simulated Body Fluid
Previous Article in Journal
The Synergistic Effect of Iodide and Sodium Nitrite on the Corrosion Inhibition of Mild Steel in Bicarbonate–Chloride Solution
Previous Article in Special Issue
Investigation of Industrial Polyurethane Foams Modified with Antimicrobial Copper Nanoparticles
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Materials 2016, 9(11), 873; doi:10.3390/ma9110873

Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses

1
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk 80-416, Poland
2
Pharmaceutical Laboratory, Avena SJ, Osielsko 86-031, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Mauro Pollini
Received: 25 July 2016 / Revised: 22 September 2016 / Accepted: 20 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Advances and Applications of Nano-antimicrobial Treatments)
View Full-Text   |   Download PDF [234 KB, uploaded 27 October 2016]

Abstract

The widespread use of contact lenses is associated with several complications, including ocular biofilm-related infections. They are very difficult to manage with standard antimicrobial therapies, because bacterial growth in a biofilm is associated with an increased antibiotic resistance. The principal aim of this study was to evaluate the efficacy of antimicrobial peptides (AMPs) in eradication of bacterial biofilms formed on commercially available contact lenses. AMPs were synthesized according to Fmoc/tBu chemistry using the solid-phase method. Minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) of the compounds were determined. Anti-biofilm activity of the antimicrobial peptides determined at different temperatures (25 °C and 37 °C) were compared with the effectiveness of commercially available contact lens solutions. All of the tested compounds exhibited stronger anti-biofilm properties as compared to those of the tested lens solutions. The strongest activity of AMPs was noticed against Gram-positive strains at a temperature of 25 °C. Conclusions: The results of our experiments encourage us toward further studies on AMPs and their potential application in the prophylaxis of contact lens-related eye infections. View Full-Text
Keywords: antimicrobial peptides; lipopeptides; biofilm; ocular infections; contact lenses antimicrobial peptides; lipopeptides; biofilm; ocular infections; contact lenses
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Maciejewska, M.; Bauer, M.; Neubauer, D.; Kamysz, W.; Dawgul, M. Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses. Materials 2016, 9, 873.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top