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Materials 2016, 9(10), 811; doi:10.3390/ma9100811

µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone

1
Atominstitut, TU Wien, Stadionallee 2, Vienna 1020, Austria
2
Institute of Physics and Materials Science, University of Natural Resources and Life Sciences (BOKU), Peter-Jordan-Straße 82, Vienna 1190, Austria
3
Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich 8093, Switzerland
4
Department of Orthopaedics and Orthopaedic Surgery, Medical University Graz, Auenbruggerplatz 5, Graz 8036, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Regine Willumeit-Römer
Received: 20 August 2016 / Revised: 24 September 2016 / Accepted: 26 September 2016 / Published: 30 September 2016
(This article belongs to the Special Issue Degradable Biomaterials Based on Magnesium Alloys)
View Full-Text   |   Download PDF [5991 KB, uploaded 30 September 2016]   |  

Abstract

This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered. View Full-Text
Keywords: elemental imaging; yttrium; magnesium; biodegradable Mg implants; bone; µXRF elemental imaging; yttrium; magnesium; biodegradable Mg implants; bone; µXRF
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Turyanskaya, A.; Rauwolf, M.; Grünewald, T.A.; Meischel, M.; Stanzl-Tschegg, S.; Löffler, J.F.; Wobrauschek, P.; Weinberg, A.M.; Lichtenegger, H.C.; Streli, C. µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone. Materials 2016, 9, 811.

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