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Materials 2016, 9(1), 47; doi:10.3390/ma9010047

Surface Functional Poly(lactic Acid) Electrospun Nanofibers for Biosensor Applications

1
Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY 14853, USA
2
Chemical and Biological Engineering Department, University at Buffalo, Buffalo, NY 14261, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Nicole Zander
Received: 24 November 2015 / Revised: 5 January 2016 / Accepted: 7 January 2016 / Published: 14 January 2016
(This article belongs to the Special Issue Electrospun Materials)
View Full-Text   |   Download PDF [1258 KB, uploaded 14 January 2016]   |  

Abstract

In this work, biotin surface functionalized hydrophilic non-water-soluble biocompatible poly(lactic acid) (PLA) nanofibers are created for their potential use as biosensors. Varying concentrations of biotin (up to 18 weight total percent (wt %)) were incorporated into PLA fibers together with poly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG) block polymers. While biotin provided surface functionalization, PLA-b-PEG provided hydrophilicity to the final fibers. Morphology and surface-available biotin of the final fibers were studied by Field Emission Scanning Electron Microscopy (FESEM) and competitive colorimetric assays. The incorporation of PLA-b-PEG block copolymers not only decreased fiber diameters but also dramatically increased the amount of biotin available at the fiber surface able to bind avidin. Finally, fiber water stability tests revealed that both biotin and PLA-b-PEG, migrated to the aqueous phase after relatively extended periods of water exposure. The functional hydrophilic nanofiber created in this work shows a potential application as a biosensor for point-of-care diagnostics. View Full-Text
Keywords: biotin; avidin; poly(lactic acid) PLA; poly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG); electrospinning; functional nanofibers biotin; avidin; poly(lactic acid) PLA; poly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG); electrospinning; functional nanofibers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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González, E.; Shepherd, L.M.; Saunders, L.; Frey, M.W. Surface Functional Poly(lactic Acid) Electrospun Nanofibers for Biosensor Applications. Materials 2016, 9, 47.

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