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Materials 2016, 9(1), 38; doi:10.3390/ma9010038

Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition

1
National Institute for Lasers, Plasma and Radiation Physics, Magurele-Ilfov 077125, Romania
2
National Institute of Materials Physics, Magurele-Ilfov 077125, Romania
3
Army Centre for Medical Research, Bucharest 020012, Romania
4
Research Centre for Advanced Materials, University of Pitesti, Pitesti 110040, Romania
5
Faculty of Materials Science and Engineering, Politehnica University of Bucharest, Bucharest 060042, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Marco Salerno
Received: 30 October 2015 / Revised: 23 December 2015 / Accepted: 6 January 2016 / Published: 13 January 2016
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Abstract

We report a study on the biocompatibility vs. thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their in vitro cytotoxicity was assessed according to ISO 10993-5 [1]. Extensive physical-chemical analyses have been carried out on the deposited structures with various thicknesses in order to explain the differences in biological behavior: profilometry, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction and surface energy measurements. XPS revealed the presence of titanium oxynitride beside TiN in amounts that vary with the film thickness. The cytocompatibility of films seems to be influenced by their TiN surface content. The thinner films seem to be more suitable for medical applications, due to the combined high values of bonding strength and superior cytocompatibility. View Full-Text
Keywords: titanium nitride; medical instrument; pull-out adherence; cytocompatibility; pulsed laser deposition titanium nitride; medical instrument; pull-out adherence; cytocompatibility; pulsed laser deposition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Duta, L.; Stan, G.E.; Popa, A.C.; Husanu, M.A.; Moga, S.; Socol, M.; Zgura, I.; Miculescu, F.; Urzica, I.; Popescu, A.C.; Mihailescu, I.N. Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition. Materials 2016, 9, 38.

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