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Materials 2015, 8(8), 4912-4931; doi:10.3390/ma8084912

Preclinical in vivo Performance of Novel Biodegradable, Electrospun Poly(lactic acid) and Poly(lactic-co-glycolic acid) Nanocomposites: A Review

1
Private Practice, Marktgasse 27, 8400 Winterthur, Switzerland
2
Clinic of Preventive Dentistry, Periodontology and Cariology, Center for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
3
Department of Cranio-Maxillofacial and Oral Surgery, Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
4
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 26 June 2015 / Revised: 26 June 2015 / Accepted: 24 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Novel Bone Substitute Materials)
View Full-Text   |   Download PDF [864 KB, uploaded 3 August 2015]   |  

Abstract

Bone substitute materials have witnessed tremendous development over the past decades and autogenous bone may still be considered the gold standard for many clinicians and clinical approaches in order to rebuild and restore bone defects. However, a plethora of novel xenogenic and synthetic bone substitute materials have been introduced in recent years in the field of bone regeneration. As the development of bone is actually a calcification process within a collagen fiber arrangement, the use of scaffolds in the formation of fibers may offer some advantages, along with additional handling characteristics. This review focuses on material characteristics and degradation behavior of electrospun biodegradable polyester scaffolds. Furthermore, we concentrated on the preclinical in vivo performance with regard to bone regeneration in preclinical studies. The major findings are as follows: Scaffold composition and architecture determine its biological behavior and degradation characteristics; The incorporation of inorganic substances and/or organic substances within composite scaffolds enhances new bone formation; L-poly(lactic acid) and poly(lactic-co-glycolic acid) composite scaffolds, especially when combined with basic substances like hydroxyapatite, tricalcium phosphate or demineralized bone powder, seem not to induce inflammatory tissue reactions in vivo. View Full-Text
Keywords: 3D scaffold; biodegradable polymer; bone; calcium phosphate; calvarial defect; electrospinning; experimental animal models; nanocomposite 3D scaffold; biodegradable polymer; bone; calcium phosphate; calvarial defect; electrospinning; experimental animal models; nanocomposite
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Holderegger, C.; Schmidlin, P.R.; Weber, F.E.; Mohn, D. Preclinical in vivo Performance of Novel Biodegradable, Electrospun Poly(lactic acid) and Poly(lactic-co-glycolic acid) Nanocomposites: A Review. Materials 2015, 8, 4912-4931.

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