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Materials 2014, 7(6), 4473-4492; doi:10.3390/ma7064473
Review

Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces

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Received: 1 April 2014; in revised form: 20 May 2014 / Accepted: 5 June 2014 / Published: 12 June 2014
(This article belongs to the Special Issue Ceramics for Healthcare 2013)
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Abstract: High-strength ceramics as materials for medical implants have a long, research-intensive history. Yet, especially on applications where the ceramic components are in direct contact with the surrounding tissue, an unresolved issue is its inherent property of biological inertness. To combat this, several strategies have been investigated over the last couple of years. One promising approach investigates the technique of Self-Assembled Monolayers (SAM) and subsequent chemical functionalization to create a biologically active tissue-facing surface layer. Implementation of this would have a beneficial impact on several fields in modern implant medicine such as hip and knee arthroplasty, dental applications and related fields. This review aims to give a summarizing overview of the latest advances in this recently emerging field, along with thorough introductions of the underlying mechanism of SAMs and surface cell attachment mechanics on the cell side.
Keywords: alumina; bioactivation; self-assembled monolayers; tissue-integration; high-strength ceramics alumina; bioactivation; self-assembled monolayers; tissue-integration; high-strength ceramics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Böke, F.; Schickle, K.; Fischer, H. Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces. Materials 2014, 7, 4473-4492.

AMA Style

Böke F, Schickle K, Fischer H. Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces. Materials. 2014; 7(6):4473-4492.

Chicago/Turabian Style

Böke, Frederik; Schickle, Karolina; Fischer, Horst. 2014. "Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces." Materials 7, no. 6: 4473-4492.


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