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New Developments of Ti-Based Alloys for Biomedical Applications
Materials 2014, 7(3), 2183-2193; doi:10.3390/ma7032183

In Vitro Cytotoxicity of a Ti-35Nb-7Zr-5Ta Alloy Doped with Different Oxygen Contents

1 UNESP—Univ. Estadual Paulista, Laboratório de Anelasticidade e Biomateriais, 17.033-360, Bauru, SP, Brazil 2 USP—Universidade de São Paulo, Faculdade de Odontologia, Departamento de Biomateriais e Biologia Oral, 05.508-900, São Paulo, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 31 October 2013 / Revised: 21 January 2014 / Accepted: 21 January 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Titanium Materials for Biomedical Application 2013)
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Cp-Ti is the most common material used for dental implants, but its elastic modulus is around five times higher than that of bone. Recently, promising alloys that add Nb, Ta, Zr and Mo to Ti have been developed. The mechanical properties of these alloys are directly related to its microstructure and the presence of interstitial elements, such as oxygen, carbon, nitrogen and hydrogen. In this study, the in vitro cytotoxicity of Ti-35Nb-7Zr-5Ta (TNZT) alloys was analyzed in the as-received condition and after being doped with several small quantities of oxygen on a cultured osteogenic cell. The cell’s morphology was also examined by scanning electron microscopy (SEM). The TNZT alloy presented no cytotoxic effects on osteoblastic cells in the studied conditions.
Keywords: Ti-35Nb-7Zr-5Ta alloy; MC3T3-E1 cells; biocompatibility; cell culture Ti-35Nb-7Zr-5Ta alloy; MC3T3-E1 cells; biocompatibility; cell culture
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Donato, T.A.G.; de Almeida, L.H.; Arana-Chavez, V.E.; Grandini, C.R. In Vitro Cytotoxicity of a Ti-35Nb-7Zr-5Ta Alloy Doped with Different Oxygen Contents. Materials 2014, 7, 2183-2193.

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