Materials 2014, 7(2), 623-636; doi:10.3390/ma7020623
Article

In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes

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Received: 16 August 2013; in revised form: 16 January 2014 / Accepted: 19 January 2014 / Published: 24 January 2014
(This article belongs to the Special Issue Titanium Materials for Biomedical Application 2013)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Polycarbonateurethanes (PCU) and polyetherurethanes (PEU) are used for medical devices, however their bio- and haemocompatibility is limited. In this study, the effect of titaniferous upgrading of different polyurethanes on the bio- and haemocompatibility was investigated by endothelial cell (EC) adhesion/proliferation and platelet adhesion (scanning electron microscopy), respectively. There was no EC adhesion/proliferation and only minor platelet adhesion on upgraded and pure PCU (Desmopan). PEUs (Texin 985, Tecothane 1085, Elastollan 1180A) differed in their cyto- and haemocompatibility. While EC adhesion depended on the type of PEU, any proliferative activity was inhibited. Additional titaniferous upgrading of PEU induced EC proliferation and increased metabolic activity. However, adherent ECs were significantly activated. While Texin was highly thrombotic, only small amounts of platelets adhered onto Tecothane and Elastollan. Additional titaniferous upgrading reduced thrombogenicity of Texin, preserved haemocompatibility of Elastollan, and increased platelet activation/aggregation on Tecothane. In conclusion, none of the PUs was cytocompatible; only titaniferous upgrading allowed EC proliferation and metabolism on PEUs. Haemocompatibility depended on the type of PU.
Keywords: endothelial cell seeding; cytocompatibility; haemocompatibility; platelet adhesion; cardiovascular tissue engineering; titanium
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MDPI and ACS Style

Lehle, K.; Li, J.; Zimmermann, H.; Hartmann, B.; Wehner, D.; Schmid, T.; Schmid, C. In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes. Materials 2014, 7, 623-636.

AMA Style

Lehle K, Li J, Zimmermann H, Hartmann B, Wehner D, Schmid T, Schmid C. In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes. Materials. 2014; 7(2):623-636.

Chicago/Turabian Style

Lehle, Karla; Li, Jing; Zimmermann, Hanngörg; Hartmann, Björn; Wehner, Daniel; Schmid, Thomas; Schmid, Christof. 2014. "In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes." Materials 7, no. 2: 623-636.

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