Next Article in Journal
Plant-Mediated Fabrication and Surface Enhanced Raman Property of Flower-Like Au@Pd Nanoparticles
Next Article in Special Issue
In vitro and in vivo Biocompatibility of Alginate Dialdehyde/Gelatin Hydrogels with and without Nanoscaled Bioactive Glass for Bone Tissue Engineering Applications
Previous Article in Journal
Review of the Potential of the Ni/Cu Plating Technique for Crystalline Silicon Solar Cells
Previous Article in Special Issue
The Effect of Exogenous Zinc Concentration on the Responsiveness of MC3T3-E1 Pre-Osteoblasts to Surface Microtopography: Part II (Differentiation)
Article Menu

Export Article

Open AccessArticle
Materials 2014, 7(2), 1342-1359; doi:10.3390/ma7021342

Gelatin-Based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro

1
Department of Cell Biology, Rostock University Medical Center, Schillingallee 69, Rostock D-18057, Germany
2
Polymer Chemistry and Biomaterials Group, Gent University, Krijgslaan 281, Building S4, Gent BE-9000, Belgium
3
DOT GmbH, Charles-Darwin-Ring 1a, Rostock D-18059, Germany
4
NMR and Structure Analysis Research Group, Gent University, Krijgslaan 281, Building S4, Gent BE-9000, Belgium
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 20 December 2013 / Revised: 24 January 2014 / Accepted: 27 January 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Biocompatibility of Materials 2013)
View Full-Text   |   Download PDF [3893 KB, uploaded 19 February 2014]   |  

Abstract

Due to the weak regeneration potential of cartilage, there is a high clinical incidence of articular joint disease, leading to a strong demand for cartilaginous tissue surrogates. The aim of this study was to evaluate a gelatin-based hydrogel for its suitability to support chondrogenic differentiation of human mesenchymal stem cells. Gelatin-based hydrogels are biodegradable, show high biocompatibility, and offer possibilities to introduce functional groups and/or ligands. In order to prove their chondrogenesis-supporting potential, a hydrogel film was developed and compared with standard cell culture polystyrene regarding the differentiation behavior of human mesenchymal stem cells. Cellular basis for this study were human adipose tissue-derived mesenchymal stem cells, which exhibit differentiation potential along the adipogenic, osteogenic and chondrogenic lineage. The results obtained show a promotive effect of gelatin-based hydrogels on chondrogenic differentiation of mesenchymal stem cells in vitro and therefore encourage subsequent in vivo studies.
Keywords: adipose tissue-derived mesenchymal stem cells (adMSC); gelatin-based hydrogels; chondrogenic differentiation; tissue engineering adipose tissue-derived mesenchymal stem cells (adMSC); gelatin-based hydrogels; chondrogenic differentiation; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Salamon, A.; van Vlierberghe, S.; van Nieuwenhove, I.; Baudisch, F.; Graulus, G.-J.; Benecke, V.; Alberti, K.; Neumann, H.-G.; Rychly, J.; Martins, J.C.; Dubruel, P.; Peters, K. Gelatin-Based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. Materials 2014, 7, 1342-1359.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top