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Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies
Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China
Department of Hematology, the Affiliated Hospital of medical College, 16 Jiangsu Road, Qingdao, Shandong 266003, China
Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266003, China
* Authors to whom correspondence should be addressed.
Received: 27 February 2013; in revised form: 24 April 2013 / Accepted: 8 May 2013 / Published: 15 May 2013
Abstract: Doxorubicin hydrochloride (DOX) is an effective anticancer agent for leukemia chemotherapy, although its clinical use has been limited because of its side effects such as cardiotoxicity, alopecia, vomiting, and leucopenia. Attention has been focussed on developing new drug carriers with high adsorption capacity and rapid adsorption rate in order to minimize the side effects of DOX. Graphene oxide (GO), a new type of nanomaterial in the carbon family, was prepared by Hummers method and used as adsorbent for DOX from aqueous solution. The physico-chemical properties of GO were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), zeta potential, and element analysis. The adsorption properties of DOX on GO were studied as a function of contact time, adsorbent dosage, temperature and pH value. The results showed that GO had a maximum adsorption capacity of 1428.57 mg/g and the adsorption isotherm data fitted the Langmuir model. The kinetics of adsorption fits a pseudo-second-order model. The thermodynamic studies indicate that the adsorption of DOX on GO is spontaneous and endothermic in nature.
Keywords: doxorubicin hydrochloride; graphene oxide; adsorption; isotherm; kinetic
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MDPI and ACS Style
Wu, S.; Zhao, X.; Li, Y.; Du, Q.; Sun, J.; Wang, Y.; Wang, X.; Xia, Y.; Wang, Z.; Xia, L. Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies. Materials 2013, 6, 2026-2042.
Wu S, Zhao X, Li Y, Du Q, Sun J, Wang Y, Wang X, Xia Y, Wang Z, Xia L. Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies. Materials. 2013; 6(5):2026-2042.
Wu, Shaoling; Zhao, Xindong; Li, Yanhui; Du, Qiuju; Sun, Jiankun; Wang, Yonghao; Wang, Xin; Xia, Yanzhi; Wang, Zonghua; Xia, Linhua. 2013. "Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies." Materials 6, no. 5: 2026-2042.