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Materials 2012, 5(9), 1661-1685; doi:10.3390/ma5091661
Review

Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

Received: 8 August 2012 / Revised: 30 August 2012 / Accepted: 5 September 2012 / Published: 17 September 2012
(This article belongs to the Special Issue Advances in Cosmetics)
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Abstract

Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed.
Keywords: inhibitors; melanogenesis; tyrosinase inhibitors; melanogenesis; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, T.-S. Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity. Materials 2012, 5, 1661-1685.

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