Oriented Collagen Scaffolds for Tissue Engineering

doi:10.3390/ma5030501

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Materials 2012, 5(3), 501-511; doi:10.3390/ma5030501

Article

Oriented Collagen Scaffolds for Tissue Engineering

Yoshihiro Isobe¹, Toru Kosaka¹, Go Kuwahara², Hiroshi Mikami², Taro Saku¹ and Shohta Kodama^2,*

¹ Atree Inc., 16-12-1 Hiroo Shibuya-ku, Tokyo, 150-0012, Japan ² Department of Regenerative Medicine & Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka Pref, 814-0133, Japan

* Author to whom correspondence should be addressed.

Received: 25 February 2012; in revised form: 6 March 2012 / Accepted: 8 March 2012 / Published: 16 March 2012

(This article belongs to the Special Issue Fibrous Scaffolds for Tissue Engineering)

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Abstract: Oriented collagen scaffolds were developed in the form of sheet, mesh and tube by arraying flow-oriented collagen string gels and dehydrating the arrayed gels. The developed collagen scaffolds can be any practical size with any direction of orientation for tissue engineering applications. The birefringence of the collagen scaffolds was quantitatively analyzed by parallel Nicols method. Since native collagen in the human body has orientations such as bone, cartilage, tendon and cornea, and the orientation has a special role for the function of human organs, the developed various types of three-dimensional oriented collagen scaffolds are expected to be useful biomaterials for tissue engineering and regenerative medicines.

Keywords: oriented collagen; three-dimensional; scaffold; biomaterial; tissue engineering

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Cite This Article

MDPI and ACS Style

Isobe, Y.; Kosaka, T.; Kuwahara, G.; Mikami, H.; Saku, T.; Kodama, S. Oriented Collagen Scaffolds for Tissue Engineering. Materials 2012, 5, 501-511.

AMA Style

Isobe Y, Kosaka T, Kuwahara G, Mikami H, Saku T, Kodama S. Oriented Collagen Scaffolds for Tissue Engineering. Materials. 2012; 5(3):501-511.

Chicago/Turabian Style

Isobe, Yoshihiro; Kosaka, Toru; Kuwahara, Go; Mikami, Hiroshi; Saku, Taro; Kodama, Shohta. 2012. "Oriented Collagen Scaffolds for Tissue Engineering." Materials 5, no. 3: 501-511.

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