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Carbon Nanomaterials: Efficacy and Safety for Nanomedicine
Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan
The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
Laboratory of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
* Authors to whom correspondence should be addressed.
Received: 16 December 2011; in revised form: 11 February 2012 / Accepted: 15 February 2012 / Published: 21 February 2012
Abstract: Carbon nanomaterials, including fullerenes, carbon nanohorns, and carbon nanotubes, are increasingly being used in various fields owing to these materials’ unique, size-dependent functions and physicochemical properties. Recently, because of their high variability and stability, carbon nanomaterials have been explored as a novel tool for the delivery of therapeutic molecules including peptide and nucleic acid cancer drugs. However, insufficient information is available regarding the safety of carbon nanomaterials for human health, even though such information is vital for the development of safe and effective nanomedicine technologies. In this review, we discuss currently available information regarding the safety of carbon nanomaterials in nanomedicine applications, including information obtained from our own studies; and we discuss types of carbon nanomaterials that demonstrate particular promise for safe nanomedicine technologies.
Keywords: nanomedicine; carbon nanomaterials; fullerenes; carbon nanohorns; carbon nanotubes; drug delivery; nano safety science
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MDPI and ACS Style
Yamashita, T.; Yamashita, K.; Nabeshi, H.; Yoshikawa, T.; Yoshioka, Y.; Tsunoda, S.-I.; Tsutsumi, Y. Carbon Nanomaterials: Efficacy and Safety for Nanomedicine. Materials 2012, 5, 350-363.
Yamashita T, Yamashita K, Nabeshi H, Yoshikawa T, Yoshioka Y, Tsunoda S-I, Tsutsumi Y. Carbon Nanomaterials: Efficacy and Safety for Nanomedicine. Materials. 2012; 5(2):350-363.
Yamashita, Takuya; Yamashita, Kohei; Nabeshi, Hiromi; Yoshikawa, Tomoaki; Yoshioka, Yasuo; Tsunoda, Shin-ichi; Tsutsumi, Yasuo. 2012. "Carbon Nanomaterials: Efficacy and Safety for Nanomedicine." Materials 5, no. 2: 350-363.