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• Kirkpatrick, D
• Weiss, M
• Naumov, A
• Bartholomeusz, G
• Weisman, R
• Gliko, O
• [+] on Google Scholar
• Kirkpatrick, D
• Weiss, M
• Naumov, A
• Bartholomeusz, G
• Weisman, R
• Gliko, O
• [+] on PubMed
• Kirkpatrick, D
• Weiss, M
• Naumov, A
• Bartholomeusz, G
• Weisman, R
• Gliko, O

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Materials 2012, 5(2), 278-301; doi:10.3390/ma5020278

Article

Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA?

D. Lynn Kirkpatrick ^1,* , Michelle Weiss ¹ , Anton Naumov ¹ , Geoffrey Bartholomeusz ² , R. Bruce Weisman ³  and Olga Gliko ¹

¹ Ensysce Biosciences Inc., 7000 Fannin St., Suite 2115, Houston, TX 77030, USA ² MD Anderson Cancer Center, 1901 East Road, Unit 1950, Houston, TX 77054, USA ³ Department of Chemistry, Rice University, 6100 Main Street, Houston, TX 77005, USA

* Author to whom correspondence should be addressed.

Received: 1 December 2011; in revised form: 2 February 2012 / Accepted: 6 February 2012 / Published: 13 February 2012

(This article belongs to the Special Issue Carbon Nanotubes: Synthesis, Characterization and Applications)

Download PDF Full-Text [1707 KB, Updated Version, uploaded 14 February 2012 14:20 CET]

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Abstract: Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nanotubes (SWCNT) have been shown to deliver siRNA to tumors in vivo. The low toxicity, the excellent membrane penetration ability, the protection afforded against blood breakdown of the siRNA payload and the good biological activity seen in vivo suggests that SWCNT may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications. This paper will introduce a short review of a number of therapeutic applications for carbon nanotubes and provide recent data suggesting SWCNT are an excellent option for the delivery of siRNA clinically.

Keywords: single-walled carbon nanotube; short interfering RNA; therapeutic delivery

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