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Materials 2012, 5(12), 2586-2596; doi:10.3390/ma5122586
Article

Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury

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1 Key Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou 310027, China 2 Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China 3 Zeo-Innov Medical Technology Corporation, Hangzhou 310023, China
* Author to whom correspondence should be addressed.
Received: 15 October 2012 / Revised: 26 November 2012 / Accepted: 27 November 2012 / Published: 3 December 2012
(This article belongs to the Special Issue Advances in Mesoporous Materials)
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Abstract

Quikclot has been used many years for treating external hemorrhage in the battle field. In this study, the hemostatic performance of NZG-JY (natural zeolite granules from Jinyun, China) was evaluated and compared with Quikclot in a lethal rabbit model of complex groin injury. Fifty-six anesthetized rabbits were randomized to three different groups: (1) NZG-JY (n = 19); (2) Quikclot (n = 19); and (3) medical gauze (n = 18). Survival was recorded three hours after the application of the hemostatic agents. The wound healing properties of the survived animals (n = 4 for each group) were observed a week later. The clotting efficiency is 100% for the animals in the NZG-JY and the Quikclot group, while only 5.6% in the gauze group. The mortality in the NZG-JY group (21.0%) is significantly less than that in the Quikclot group (52.6%) and the gauze group (66.7%). A good healing property was achieved in all animals that survived in the NZG-JY group, while three quarters of the animals in the Quikclot group had serious necrotic tissue. NZG-JY significantly decreases the mortality in a lethal rabbit model of complex groin injury and demonstrates good healing properties.
Keywords: natural zeolite; hemostatic efficiency; mortality; wound healing; groin injury natural zeolite; hemostatic efficiency; mortality; wound healing; groin injury
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, Y.; Li, H.; Xiao, L.; Zhou, L.; Shentu, J.; Zhang, X.; Fan, J. Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury. Materials 2012, 5, 2586-2596.

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