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Materials 2012, 5(11), 2292-2305; doi:10.3390/ma5112292
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Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells

1,*  and 2,*
1 School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Nomi, Ishikawa 923-1292, Japan 2 Faculty of Life and Medical Sciences, Doshisha University, 1-3, Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan
* Authors to whom correspondence should be addressed.
Received: 18 October 2012 / Revised: 8 November 2012 / Accepted: 8 November 2012 / Published: 13 November 2012
(This article belongs to the Special Issue Supported Lipid Membranes)
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Abstract

Recent developments in studies concerning cell-sized vesicles, such as liposomes with a lipid bilayer and water-in-oil droplets covered by a lipid monolayer, aim to realize the real-world modeling of living cells. Compartmentalization with a membrane boundary is essential for the organization of living systems. Due to the relatively large surface/volume ratio in microconfinement, the membrane interface influences phenomena related to biological functions. In this article, we mainly focus on the following subjects: (i) conformational transition of biopolymers in a confined space; (ii) molecular association on the membrane surface; and (iii) remote control of cell-sized membrane morphology.
Keywords: liposome; droplet; cell-sized confinement; lipid membrane; DNA; compartmentalization; nanoparticle liposome; droplet; cell-sized confinement; lipid membrane; DNA; compartmentalization; nanoparticle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hamada, T.; Yoshikawa, K. Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells. Materials 2012, 5, 2292-2305.

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