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Drug-Eluting Intraocular Lenses
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain
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Received: 6 October 2011; in revised form: 20 October 2011 / Accepted: 25 October 2011 / Published: 1 November 2011
Abstract: Notable advances in materials science and in surgical techniques make the management of cataract by replacement of the opaque crystalline with an intraocular lens (IOL), one of the most cost-effective interventions in current healthcare. The usefulness and safety of IOLs can be enhanced if they are endowed with the ability to load and to sustain drug release in the implantation site. Drug-eluting IOLs can prevent infections and untoward reactions of eye tissues (which lead to opacification) and also can act as drug depots for treatment of several other ocular pathologies. Such a myriad of therapeutic possibilities has prompted the design of drug-IOL combination products. Several approaches are under study, namely combination of the IOL with an insert in a single device, soaking in drug solutions, impregnation using supercritical fluids, coating with drug/polymer layers, and covalent grafting of the drug. The advantages/limitations of each technique are discussed in the present review on selected examples. Although more in vivo data are required, the information already available proves the interest of some approaches in ocular therapeutics.
Keywords: intraocular lens; drug delivery; combination product; hydrogel; drug soaking; supercritical fluids; posterior capsule opacification
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González-Chomón, C.; Concheiro, A.; Alvarez-Lorenzo, C. Drug-Eluting Intraocular Lenses. Materials 2011, 4, 1927-1940.
González-Chomón C, Concheiro A, Alvarez-Lorenzo C. Drug-Eluting Intraocular Lenses. Materials. 2011; 4(11):1927-1940.
González-Chomón, Clara; Concheiro, Angel; Alvarez-Lorenzo, Carmen. 2011. "Drug-Eluting Intraocular Lenses." Materials 4, no. 11: 1927-1940.