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Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium
Department of Molecular and Cellular Anatomy, University of Regensburg, University Street 31, 93053 Regensburg, Germany
* Author to whom correspondence should be addressed.
Received: 16 January 2010; in revised form: 15 March 2010 / Accepted: 26 March 2010 / Published: 26 March 2010
Abstract: Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials.
Keywords: polyester fleece; artificial interstitium; kidney; stem/progenitor cells; regeneration; aldosterone
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MDPI and ACS Style
Minuth, W.W.; Denk, L.; Glashauser, A. Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium. Materials 2010, 3, 2369-2392.
Minuth WW, Denk L, Glashauser A. Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium. Materials. 2010; 3(4):2369-2392.
Minuth, Will W.; Denk, Lucia; Glashauser, Anne. 2010. "Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium." Materials 3, no. 4: 2369-2392.