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Materials 2010, 3(4), 2369-2392; doi:10.3390/ma3042369

Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium

Department of Molecular and Cellular Anatomy, University of Regensburg, University Street 31, 93053 Regensburg, Germany
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Received: 16 January 2010 / Revised: 15 March 2010 / Accepted: 26 March 2010 / Published: 26 March 2010
(This article belongs to the Special Issue Advances in Biomaterials)
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Abstract

Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials. View Full-Text
Keywords: polyester fleece; artificial interstitium; kidney; stem/progenitor cells; regeneration; aldosterone polyester fleece; artificial interstitium; kidney; stem/progenitor cells; regeneration; aldosterone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Minuth, W.W.; Denk, L.; Glashauser, A. Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium. Materials 2010, 3, 2369-2392.

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