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Materials 2010, 3(3), 1803-1832; doi:10.3390/ma3031803
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Surface Engineering and Patterning Using Parylene for Biological Applications

1,2
 and
2,*
1 Department of Biomedical Engineering, Cornell University, Ithaca, New York, NY 14853, USA 2 School of Applied and Engineering Physics, Cornell University, Ithaca, New York, NY 14853, USA
* Author to whom correspondence should be addressed.
Received: 1 February 2010 / Accepted: 11 March 2010 / Published: 15 March 2010
(This article belongs to the Special Issue Advances in Biomaterials)

Abstract

Parylene is a family of chemically vapour deposited polymer with material properties that are attractive for biomedicine and nanobiotechnology. Chemically inert parylene “peel-off” stencils have been demonstrated for micropatterning biomolecular arrays with high uniformity, precise spatial control down to nanoscale resolution. Such micropatterned surfaces are beneficial in engineering biosensors and biological microenvironments. A variety of substituted precursors enables direct coating of functionalised parylenes onto biomedical implants and microfluidics, providing a convenient method for designing biocompatible and bioactive surfaces. This article will review the emerging role and applications of parylene as a biomaterial for surface chemical modification and provide a future outlook.
Keywords: parylene; micropatterning; surface modification; [2.2]paracyclophane; biomaterial; bioactive; biomolecular; nanobiotechnology; microarray; microfluidic parylene; micropatterning; surface modification; [2.2]paracyclophane; biomaterial; bioactive; biomolecular; nanobiotechnology; microarray; microfluidic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tan, C.P.; Craighead, H.G. Surface Engineering and Patterning Using Parylene for Biological Applications. Materials 2010, 3, 1803-1832.

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