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Materials 2017, 10(9), 1052; doi:10.3390/ma10091052

Release of VEGF from Dental Implant Improves Osteogenetic Process: Preliminary In Vitro Tests

Department of Biomedical Sciences, University of Padova, via G. Colombo 3, 35100 Padova, Italy
Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy
Department of Neurosciences, University of Padova, via Giustiniani 5, 35100 Padova, Italy
Department of Medical, Oral, and Biotechnological Sciences, University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
Department of Otolaryngology, Head and Neck and Maxillofacial Surgery, Sackler Faculty of Medicine, Tel-Aviv Sourasky Medical Center, Tel Aviv University, 6 Weitzman Street, 64239 Tel Aviv, Israel
Author to whom correspondence should be addressed.
Received: 10 August 2017 / Revised: 24 August 2017 / Accepted: 1 September 2017 / Published: 8 September 2017
(This article belongs to the Special Issue Dental Implant Materials)
View Full-Text   |   Download PDF [5437 KB, uploaded 8 September 2017]   |  


Introduction: During osseointegration process, the presence of an inflammatory event could negatively influence the proper osteogenetic ability of the implant surface. In order to reduce this possibility, an implementation of angiogenetic event through the release of Vascular Endothelial Growth Factor (VEGF) can be a tool as co-factor for osteoblastic differentiation. In this paper, novel dental implant surfaces enriched with VEGF have been tested. Material and methods: The ability of VEGF-enriched titanium implants to improve the osteogenetic properties of Mesenchymal stem cells (MSC), also in the presence of an inflammatory environment, have been in vitro tested. Molecular biology, morphological analyses, and biochemical tests have been performed in order to confirm biological properties of these surfaces. Results: Our results confirm that the presence of VEGF onto the implant surface is able not only to protect the cells from in vitro aging and from Reactive Oxygen Species (ROS) damage, but it also improves their osteogenic and endothelial differentiation, even in the presence of inflammatory cytokines. Conclusion: This study establishes a biologically powerful novel tool that could enhance bone repair in dental implant integration. View Full-Text
Keywords: biomimetic material; cell adhesion; osteogenesis; osseointegration; vascular endothelial growth factor biomimetic material; cell adhesion; osteogenesis; osseointegration; vascular endothelial growth factor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zavan, B.; Ferroni, L.; Gardin, C.; Sivolella, S.; Piattelli, A.; Mijiritsky, E. Release of VEGF from Dental Implant Improves Osteogenetic Process: Preliminary In Vitro Tests. Materials 2017, 10, 1052.

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