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Materials 2017, 10(7), 686; doi:10.3390/ma10070686

Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications

1
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Spl. Independentei, 050095 Bucharest, Romania
2
Department of Analytical Chemistry and Environmental Engineering, Politehnica University of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
3
Department of Clinical Sciences, University of Agricultural Sciences and Veterinary Medicine, 105 Spl. Independentei, 050097 Bucharest, Romania
4
Pathology Department, University of Agricultural Sciences and Veterinary Medicine, 105 Spl. Independentei, 050097 Bucharest, Romania
5
Materials Processing Department, Politehnica University of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
6
Machines and Manufacturing Systems Department, Politehnica University of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
7
Department of Metallic Materials Science, Physical Metallurgy, Politehnica University of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
8
Experimental Physics Department, National Research Tomsk Polytechnic University, Lenin Avenue 43, 634050 Tomsk, Russia
9
SC R&D Consulting and Services SRL, 45 Maria Ghiculeasa, 023761 Bucharest, Romania
Both authors contributed equally to this work
*
Author to whom correspondence should be addressed.
Received: 26 April 2017 / Revised: 12 June 2017 / Accepted: 19 June 2017 / Published: 22 June 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [6125 KB, uploaded 23 June 2017]   |  

Abstract

Despite their good biocompatibility and adequate mechanical behavior, the main limitation of Mg alloys might be their high degradation rates in a physiological environment. In this study, a novel Mg-based alloy exhibiting an elastic modulus E = 42 GPa, Mg-1Ca-0.2Mn-0.6Zr, was synthesized and thermo-mechanically processed. In order to improve its performance as a temporary bone implant, a coating based on cellulose acetate (CA) was realized by using the dipping method. The formation of the polymer coating was demonstrated by FT-IR, XPS, SEM and corrosion behavior comparative analyses of both uncoated and CA-coated alloys. The potentiodynamic polarization test revealed that the CA coating significantly improved the corrosion resistance of the Mg alloy. Using a series of in vitro and in vivo experiments, the biocompatibility of both groups of biomaterials was assessed. In vitro experiments demonstrated that the media containing their extracts showed good cytocompatibility on MC3T3-E1 pre-osteoblasts in terms of cell adhesion and spreading, viability, proliferation and osteogenic differentiation. In vivo studies conducted in rats revealed that the intramedullary coated implant for fixation of femur fracture was more efficient in inducing bone regeneration than the uncoated one. In this manner, the present study suggests that the CA-coated Mg-based alloy holds promise for orthopedic aplications. View Full-Text
Keywords: magnesium alloy; cellulose acetate coating; corrosion; osteoblast; in vivo behavior magnesium alloy; cellulose acetate coating; corrosion; osteoblast; in vivo behavior
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Neacsu, P.; Staras, A.I.; Voicu, S.I.; Ionascu, I.; Soare, T.; Uzun, S.; Cojocaru, V.D.; Pandele, A.M.; Croitoru, S.M.; Miculescu, F.; Cotrut, C.M.; Dan, I.; Cimpean, A. Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications. Materials 2017, 10, 686.

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