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Open AccessCommunication
Materials 2017, 10(2), 191; doi:10.3390/ma10020191

A Dual-Bonded Approach for Improving Hydrogel Implant Stability in Cartilage Defects

1
Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China
2
Department of Electronic Communication & Software Engineering, Nanfang College of Sun Yat-sen University, Guangzhou 510970, China
3
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Arne Berner
Received: 9 December 2016 / Revised: 22 January 2017 / Accepted: 6 February 2017 / Published: 16 February 2017
View Full-Text   |   Download PDF [5571 KB, uploaded 16 February 2017]   |  

Abstract

Integration and stability of hydrogels and surrounding cartilage/bone tissue is crucial for both immediate functionality and long-term performance of the tissue. In this work, chondroitin sulphate (CS) a polysaccharide found in cartilage and other tissues was used to synthesize a tough hydrogel that was chemically functionalized with methacrylate and aldehyde groups, bonding to surrounding tissue via a dual-bonded approach. The hydrogel can not only chemically anchor onto implanted titanium at the subchondral bone, but also on cartilage tissue via the Schiff-base reaction. In vitro experiments confirmed that the strategy improved hydrogel implant stability with cartilage tissue, was favorable for chondrocyte attachment, and has the potential to quickly and effectively repair cartilage defects and maintain joint functionality for a long time. View Full-Text
Keywords: titanium; chondroitin sulphate; cartilage tissue; aldehyde; adhesion titanium; chondroitin sulphate; cartilage tissue; aldehyde; adhesion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, Y.; Wu, Y.; Zhou, L.; Wang, Z.; Dai, C.; Ning, C.; Tan, G. A Dual-Bonded Approach for Improving Hydrogel Implant Stability in Cartilage Defects. Materials 2017, 10, 191.

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