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Materials 2017, 10(11), 1256; doi:10.3390/ma10111256

Calcium Phosphate Cement with Antimicrobial Properties and Radiopacity as an Endodontic Material

Department of Dental Hygiene, China Medical University, Taichung 404, Taiwan
School of Dentistry, College of Medicine, China Medical University, Taichung 404, Taiwan
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 112, Taiwan
Advanced Medical Devices and Composites Laboratory, Feng Chia University, Taichung 407, Taiwan
Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan
Contribution equal to first author.
Author to whom correspondence should be addressed.
Received: 8 September 2017 / Revised: 13 October 2017 / Accepted: 27 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Dental Biomaterials 2017)
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Calcium phosphate cements (CPCs) have several advantages for use as endodontic materials, and such advantages include ease of use, biocompatibility, potential hydroxyapatite-forming ability, and bond creation between the dentin and appropriate filling materials. However, unlike tricalcium silicate (CS)-based materials, CPCs do not have antibacterial properties. The present study doped a nonwashable CPC with 0.25–1.0 wt % hinokitiol and added 0, 5, and 10 wt % CS. The CPCs with 0.25–0.5 wt % hinokitiol showed appreciable antimicrobial properties without alterations in their working or setting times, mechanical properties, or cytocompatibility. Addition of CS slightly retarded the apatite formation of CPC and the working and setting time was obviously reduced. Moreover, addition of CS dramatically increased the compressive strength of CPC. Doping CS with 5 wt % ZnO provided additional antibacterial effects to the present CPC system. CS and hinokitiol exerted a synergic antibacterial effect, and the CPC with 0.25 wt % hinokitiol and 10 wt % CS (doped with 5 wt % ZnO) had higher antibacterial properties than that of pure CS. The addition of 10 wt % bismuth subgallate doubled the CPC radiopacity. The results demonstrate that hinokitiol and CS can improve the antibacterial properties of CPCs, and they can thus be considered for endodontic applications. View Full-Text
Keywords: calcium phosphate cement; hinokitiol; tricalcium silicates; endodontic materials; antibacterial calcium phosphate cement; hinokitiol; tricalcium silicates; endodontic materials; antibacterial

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shieh, T.-M.; Hsu, S.-M.; Chang, K.-C.; Chen, W.-C.; Lin, D.-J. Calcium Phosphate Cement with Antimicrobial Properties and Radiopacity as an Endodontic Material. Materials 2017, 10, 1256.

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