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Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins
Universidad de los Andes, Bogotá, Colombia, Grupo de Investigación en Sólidos Porosos y Calorimetría, Departamento de Química, Facultad de Ciencias / Carrera 1 No.18 A10, Bogotá, Colombia
Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química / Ciudad Universitaria, Bogotá Colombia
* Author to whom correspondence should be addressed.
Received: 4 July 2008; in revised form: 11 October 2008 / Accepted: 14 October 2008 / Published: 16 October 2008
Abstract: The interaction of guest molecules ranging from pentan-1-ol to octan-1-ol with α-cyclodextrin (α-CD) in water of has been studied calorimetrically at 283.15, 288.15, 293.15, 298.15 and 308.15 K with an isoperibolic titration calorimeter designed in our laboratory. The calorimetric method employed allows the determination of the thermodynamic parameters characterizing the binding process, ΔG°m, ΔH°m, ΔS°mand ΔCp°, namely free energy, enthalpy, and calorific capacity. These results show that in the temperature range investigated, the entropy change increased with chain length. This is in line with what is expected for a hydrophobic dehydration process. However, that effect is not expected to lead to the more pronounced negative CH2-increment observed for nc > 5 or 6. As for many other ligand binding processes, we can observe a significant enthalpy - entropy compensation for this system, both with respect to temperature and structure.
Keywords: Isoperibolic titration calorimetry; Cyclodextrins; Thermodynamic properties
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Moreno-Piraján, J.C.; Giraldo, L. Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins. Energies 2008, 1, 93-104.
Moreno-Piraján JC, Giraldo L. Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins. Energies. 2008; 1(3):93-104.
Moreno-Piraján, Juan C.; Giraldo, Liliana. 2008. "Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins." Energies 1, no. 3: 93-104.