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Alcohol Consumption and Oxidative DNA Damage
Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0135, Japan
Received: 1 June 2011; in revised form: 5 July 2011 / Accepted: 6 July 2011 / Published: 14 July 2011
Abstract: To examine the effects of alcohol consumption on cancer risk, we measured oxidative DNA damage and its repair activity in the livers and esophagi of rats fed with ethanol. Using our previously designed protocol for feeding rats with a high concentration of ethanol, we examined the effects of ethanol consumption on 8-oxo-Gua generation and repair activity in the livers and esophagi of rats. We found that a high concentration of ethanol accompanied with a vitamin-depleted diet increased 8-oxo-Gua and its repair activity. 8-Oxo-Gua is known to induce point mutations, leading to carcinogenesis. Therefore, these results suggested that a high concentration of ethanol and an irregular diet increased liver and esophageal cancer risk. On the other hand, we showed that a low concentration of ethanol decreased 8-oxo-Gua and its repair activity in the livers of mice treated with a carcinogen. Taken together, the effects of ethanol consumption on cancer risk depend on the ethanol concentration and the diet pattern.
Keywords: alcohol; 7,8-dihydro-8-oxoguanine; 8-oxoguanine DNA glycosylase 1; reactive oxygen species; vitamin-depleted diet
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MDPI and ACS Style
Hirano, T. Alcohol Consumption and Oxidative DNA Damage. Int. J. Environ. Res. Public Health 2011, 8, 2895-2906.
Hirano T. Alcohol Consumption and Oxidative DNA Damage. International Journal of Environmental Research and Public Health. 2011; 8(7):2895-2906.
Hirano, Takeshi. 2011. "Alcohol Consumption and Oxidative DNA Damage." Int. J. Environ. Res. Public Health 8, no. 7: 2895-2906.