Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Environ. Res. Public Health 2011, 8(6), 2533-2555; doi:10.3390/ijerph8062533
Review

Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid

1,*  and 2
Received: 27 November 2010; in revised form: 12 January 2011 / Accepted: 13 January 2011 / Published: 23 June 2011
View Full-Text   |   Download PDF [403 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse or retard diseases caused by oxidative and inflammatory processes. Vernonia amygdalina is a perennial herb belonging to the Asteraceae family. Extracts of the plant have been used in various folk medicines as remedies against helminthic, protozoal and bacterial infections with scientific support for these claims. Phytochemicals such as saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, edotides and sesquiterpenes have been extracted and isolated from Vernonia amygdalina. These compounds elicit various biological effects including cancer chemoprevention. Garcinia kola (Guttiferae) seed, known as “bitter kola”, plays an important role in African ethnomedicine and traditional hospitality. It is used locally to treat illnesses like colds, bronchitis, bacterial and viral infections and liver diseases. A number of useful phytochemicals have been isolated from the seed and the most prominent of them is the Garcinia bioflavonoids mixture called kolaviron. It has well-defined structure and an array of biological activities including antioxidant, antidiabetic, antigenotoxic and hepatoprotective properties. The chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoids have been attributed to their abilities to scavenge free radicals, induce detoxification, inhibit stress response proteins and interfere with DNA binding activities of some transcription factors.
Keywords: Garcinia kola; Vernonia amygdalina; kolaviron; epivernodalol; antioxidants; chemoprevention Garcinia kola; Vernonia amygdalina; kolaviron; epivernodalol; antioxidants; chemoprevention
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Farombi, E.O.; Owoeye, O. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. Int. J. Environ. Res. Public Health 2011, 8, 2533-2555.

AMA Style

Farombi EO, Owoeye O. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. International Journal of Environmental Research and Public Health. 2011; 8(6):2533-2555.

Chicago/Turabian Style

Farombi, Ebenezer O.; Owoeye, Olatunde. 2011. "Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid." Int. J. Environ. Res. Public Health 8, no. 6: 2533-2555.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert