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Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria
* Author to whom correspondence should be addressed.
Received: 27 November 2010; in revised form: 12 January 2011 / Accepted: 13 January 2011 / Published: 23 June 2011
Abstract: Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse or retard diseases caused by oxidative and inflammatory processes. Vernonia amygdalina is a perennial herb belonging to the Asteraceae family. Extracts of the plant have been used in various folk medicines as remedies against helminthic, protozoal and bacterial infections with scientific support for these claims. Phytochemicals such as saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, edotides and sesquiterpenes have been extracted and isolated from Vernonia amygdalina. These compounds elicit various biological effects including cancer chemoprevention. Garcinia kola (Guttiferae) seed, known as “bitter kola”, plays an important role in African ethnomedicine and traditional hospitality. It is used locally to treat illnesses like colds, bronchitis, bacterial and viral infections and liver diseases. A number of useful phytochemicals have been isolated from the seed and the most prominent of them is the Garcinia bioflavonoids mixture called kolaviron. It has well-defined structure and an array of biological activities including antioxidant, antidiabetic, antigenotoxic and hepatoprotective properties. The chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoids have been attributed to their abilities to scavenge free radicals, induce detoxification, inhibit stress response proteins and interfere with DNA binding activities of some transcription factors.
Keywords: Garcinia kola; Vernonia amygdalina; kolaviron; epivernodalol; antioxidants; chemoprevention
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MDPI and ACS Style
Farombi, E.O.; Owoeye, O. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. Int. J. Environ. Res. Public Health 2011, 8, 2533-2555.
Farombi EO, Owoeye O. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. International Journal of Environmental Research and Public Health. 2011; 8(6):2533-2555.
Farombi, Ebenezer O.; Owoeye, Olatunde. 2011. "Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid." Int. J. Environ. Res. Public Health 8, no. 6: 2533-2555.