Next Article in Journal
Spatial Pattern Analysis of Heavy Metals in Beijing Agricultural Soils Based on Spatial Autocorrelation Statistics
Next Article in Special Issue
Maximum Cumulative Ratio (MCR) as a Tool for Assessing the Value of Performing a Cumulative Risk Assessment
Previous Article in Journal
Cancer Incidence and Mortality in Swedish Sterilant Workers Exposed to Ethylene Oxide: Updated Cohort Study Findings 1972–2006
Previous Article in Special Issue
Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment
Int. J. Environ. Res. Public Health 2011, 8(6), 2020-2073; doi:10.3390/ijerph8062020
Review

Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and Potential Air Pollutant Interactions

1,* , 1
, 2
 and 3
Received: 24 April 2011; Accepted: 20 May 2011 / Published: 8 June 2011
(This article belongs to the Special Issue Cumulative Health Risk Assessment)
View Full-Text   |   Download PDF [592 KB, uploaded 19 June 2014]
Abstract: Regulatory agencies are under increased pressure to consider broader public health concerns that extend to multiple pollutant exposures, multiple exposure pathways, and vulnerable populations. Specifically, cumulative risk assessment initiatives have stressed the importance of considering both chemical and non-chemical stressors, such as socioeconomic status (SES) and related psychosocial stress, in evaluating health risks. The integration of non-chemical stressors into a cumulative risk assessment framework has been largely driven by evidence of health disparities across different segments of society that may also bear a disproportionate risk from chemical exposures. This review will discuss current efforts to advance the field of cumulative risk assessment, highlighting some of the major challenges, discussed within the construct of the traditional risk assessment paradigm. Additionally, we present a summary of studies of potential interactions between social stressors and air pollutants on health as an example of current research that supports the incorporation of non-chemical stressors into risk assessment. The results from these studies, while suggestive of possible interactions, are mixed and hindered by inconsistent application of social stress indicators. Overall, while there have been significant advances, further developments across all of the risk assessment stages (i.e., hazard identification, exposure assessment, dose-response, and risk characterization) are necessary to provide a scientific basis for regulatory actions and effective community interventions, particularly when considering non-chemical stressors. A better understanding of the biological underpinnings of social stress on disease and implications for chemical-based dose-response relationships is needed. Furthermore, when considering non-chemical stressors, an appropriate metric, or series of metrics, for risk characterization is also needed. Cumulative risk assessment research will benefit from coordination of information from several different scientific disciplines, including, for example, toxicology, epidemiology, nutrition, neurotoxicology, and the social sciences.
Keywords: cumulative risk assessment; vulnerable populations; socioeconomic status; social stress; air pollutants cumulative risk assessment; vulnerable populations; socioeconomic status; social stress; air pollutants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Lewis, A.S.; Sax, S.N.; Wason, S.C.; Campleman, S.L. Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and Potential Air Pollutant Interactions. Int. J. Environ. Res. Public Health 2011, 8, 2020-2073.

AMA Style

Lewis AS, Sax SN, Wason SC, Campleman SL. Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and Potential Air Pollutant Interactions. International Journal of Environmental Research and Public Health. 2011; 8(6):2020-2073.

Chicago/Turabian Style

Lewis, Ari S.; Sax, Sonja N.; Wason, Susan C.; Campleman, Sharan L. 2011. "Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and Potential Air Pollutant Interactions." Int. J. Environ. Res. Public Health 8, no. 6: 2020-2073.


Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert