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Int. J. Environ. Res. Public Health 2011, 8(12), 4596-4607; doi:10.3390/ijerph8124596

Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance

Received: 28 October 2011 / Revised: 2 December 2011 / Accepted: 7 December 2011 / Published: 12 December 2011
(This article belongs to the Special Issue Childhood Obesity: Prevention and Treatment)
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Increased adiposity and unhealthy lifestyle augment the risk for type 2 diabetes in children with familial predisposition. Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. This study was conducted to investigate parental, physiological, behavioral and socio-economic factors related to IR in Korean children. This study is a cross-sectional study using data from 111 children aged 7 years and their parents. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using fasting glucose and insulin level as a marker of IR. All children’s adiposity indices (r = 0.309–0.318, all P-value = 0.001) and maternal levels of fasting insulin (r = 0.285, P-value = 0.003) and HOMA-IR (r = 0.290, P-value = 0.002) were positively correlated with children’s HOMA-IR level. There was no statistical difference of children’s HOMA-IR level according to children’s lifestyle habits and socioeconomic status of families. An increase of 1 percentage point in body fat was related to 2.7% increase in children’s HOMA-IR (P-value < 0.001) and an increase of 1% of maternal level of HOMA-IR was related to 0.2% increase in children’s HOMA-IR (P-value = 0.002). This study shows that children’s adiposity and maternal IR are positively associated with children’s IR.
Keywords: insulin resistance; child; parent; adiposity; lifestyle habit insulin resistance; child; parent; adiposity; lifestyle habit
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cho, Y.-G.; Kang, J.-H.; Hur, Y.-I.; Song, J.; Lee, K.-S. Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance. Int. J. Environ. Res. Public Health 2011, 8, 4596-4607.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert