Abstract: Increased adiposity and unhealthy lifestyle augment the risk for type 2 diabetes in children with familial predisposition. Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. This study was conducted to investigate parental, physiological, behavioral and socio-economic factors related to IR in Korean children. This study is a cross-sectional study using data from 111 children aged 7 years and their parents. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using fasting glucose and insulin level as a marker of IR. All children’s adiposity indices (r = 0.309–0.318, all P-value = 0.001) and maternal levels of fasting insulin (r = 0.285, P-value = 0.003) and HOMA-IR (r = 0.290, P-value = 0.002) were positively correlated with children’s HOMA-IR level. There was no statistical difference of children’s HOMA-IR level according to children’s lifestyle habits and socioeconomic status of families. An increase of 1 percentage point in body fat was related to 2.7% increase in children’s HOMA-IR (P-value < 0.001) and an increase of 1% of maternal level of HOMA-IR was related to 0.2% increase in children’s HOMA-IR (P-value = 0.002). This study shows that children’s adiposity and maternal IR are positively associated with children’s IR.
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Cho, Y.-G.; Kang, J.-H.; Hur, Y.-I.; Song, J.; Lee, K.-S. Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance. Int. J. Environ. Res. Public Health 2011, 8, 4596-4607.
Cho Y-G, Kang J-H, Hur Y-I, Song J, Lee K-S. Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance. International Journal of Environmental Research and Public Health. 2011; 8(12):4596-4607.
Cho, Young-Gyu; Kang, Jae-Heon; Hur, Yang-Im; Song, Jihyun; Lee, Kang-Sook. 2011. "Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance." Int. J. Environ. Res. Public Health 8, no. 12: 4596-4607.