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Int. J. Environ. Res. Public Health 2010, 7(4), 1448-1466; doi:10.3390/ijerph7041448

Alcoholism and Alternative Splicing of Candidate Genes

Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan
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Received: 26 February 2010 / Revised: 21 March 2010 / Accepted: 23 March 2010 / Published: 30 March 2010
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Abstract

Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism. View Full-Text
Keywords: alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sasabe, T.; Ishiura, S. Alcoholism and Alternative Splicing of Candidate Genes. Int. J. Environ. Res. Public Health 2010, 7, 1448-1466.

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