Next Article in Journal
Implementation of a 3D Coupled Hydrodynamic and Contaminant Fate Model for PCDD/Fs in Thau Lagoon (France): The Importance of Atmospheric Sources of Contamination
Previous Article in Journal
Alcohol Trajectories over Three Years in a Swedish Residence Hall Student Population
Int. J. Environ. Res. Public Health 2010, 7(4), 1448-1466; doi:10.3390/ijerph7041448
Review

Alcoholism and Alternative Splicing of Candidate Genes

 and
*
Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan
* Author to whom correspondence should be addressed.
Received: 26 February 2010 / Revised: 21 March 2010 / Accepted: 23 March 2010 / Published: 30 March 2010
View Full-Text   |   Download PDF [214 KB, uploaded 19 June 2014]

Abstract

Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.
Keywords: alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Sasabe, T.; Ishiura, S. Alcoholism and Alternative Splicing of Candidate Genes. Int. J. Environ. Res. Public Health 2010, 7, 1448-1466.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert