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Int. J. Environ. Res. Public Health 2010, 7(4), 1448-1466; doi:10.3390/ijerph7041448
Review

Alcoholism and Alternative Splicing of Candidate Genes

 and *
Received: 26 February 2010; in revised form: 21 March 2010 / Accepted: 23 March 2010 / Published: 30 March 2010
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Abstract: Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.
Keywords: alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin alcoholism; alternative splicing; dopamine; NMDA; GABA; voltage-gated calcium channel; neurexin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sasabe, T.; Ishiura, S. Alcoholism and Alternative Splicing of Candidate Genes. Int. J. Environ. Res. Public Health 2010, 7, 1448-1466.

AMA Style

Sasabe T, Ishiura S. Alcoholism and Alternative Splicing of Candidate Genes. International Journal of Environmental Research and Public Health. 2010; 7(4):1448-1466.

Chicago/Turabian Style

Sasabe, Toshikazu; Ishiura, Shoichi. 2010. "Alcoholism and Alternative Splicing of Candidate Genes." Int. J. Environ. Res. Public Health 7, no. 4: 1448-1466.


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