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Int. J. Environ. Res. Public Health 2010, 7(1), 229-268; doi:10.3390/ijerph7010229
Article

Advancing the Selection of Neurodevelopmental Measures in Epidemiological Studies of Environmental Chemical Exposure and Health Effects

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Received: 27 November 2009; Accepted: 11 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Advances in Epidemiology)
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Abstract: With research suggesting increasing incidence of pediatric neurodevelopmental disorders, questions regarding etiology continue to be raised. Neurodevelopmental function tests have been used in epidemiology studies to evaluate relationships between environmental chemical exposures and neurodevelopmental deficits. Limitations of currently used tests and difficulties with their interpretation have been described, but a comprehensive critical examination of tests commonly used in studies of environmental chemicals and pediatric neurodevelopmental disorders has not been conducted. We provide here a listing and critical evaluation of commonly used neurodevelopmental tests in studies exploring effects from chemical exposures and recommend measures that are not often used, but should be considered. We also discuss important considerations in selecting appropriate tests and provide a case study by reviewing the literature on polychlorinated biphenyls.
Keywords: neurodevelopmental measures; neurodevelopment; polychlorinated biphenyls; PCBs; children’s health; domain; psychometrics; developmental epidemiology neurodevelopmental measures; neurodevelopment; polychlorinated biphenyls; PCBs; children’s health; domain; psychometrics; developmental epidemiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Youngstrom, E.; S. LaKind, J.; Kenworthy, L.; Lipkin, P.H.; Goodman, M.; Squibb, K.; R. Mattison, D.; J. Anthony, B.; Gutermuth Anthony, L. Advancing the Selection of Neurodevelopmental Measures in Epidemiological Studies of Environmental Chemical Exposure and Health Effects. Int. J. Environ. Res. Public Health 2010, 7, 229-268.

AMA Style

Youngstrom E, S. LaKind J, Kenworthy L, Lipkin PH, Goodman M, Squibb K, R. Mattison D, J. Anthony B, Gutermuth Anthony L. Advancing the Selection of Neurodevelopmental Measures in Epidemiological Studies of Environmental Chemical Exposure and Health Effects. International Journal of Environmental Research and Public Health. 2010; 7(1):229-268.

Chicago/Turabian Style

Youngstrom, Eric; S. LaKind, Judy; Kenworthy, Lauren; Lipkin, Paul H.; Goodman, Michael; Squibb, Katherine; R. Mattison, Donald; J. Anthony, Bruno; Gutermuth Anthony, Laura. 2010. "Advancing the Selection of Neurodevelopmental Measures in Epidemiological Studies of Environmental Chemical Exposure and Health Effects." Int. J. Environ. Res. Public Health 7, no. 1: 229-268.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert